WebbAbstract Background: Total neoadjuvant therapy (TNT) is a novel approach for locally advanced rectal cancer (LARC), which attempts to deliver both systemic chemotherapy and neoadjuvant chemoradiotherapy prior to surgery. However, its efficacy and safety remain controversial in randomized controlled trials (RCTs). Webb26 nov. 2024 · The oncologic benefit of TNT demonstrated in PRODIGE 23 is corroborated by the findings of the RAPIDO (Rectal Cancer and Preoperative Induction Therapy followed by Dedicated Operation) trial, 6 conducted at 54 centers in Europe. Patients were randomly assigned to TNT (462 patients) or standard treatment (450 patients).
‘Test n Treat (TnT)’: a cluster-randomised feasibility trial of ...
Webb21 okt. 2024 · Background: In the TNT trial of triple negative breast cancer (NCT00532727), germline BRCA1/2 mutations were present in 28% of carboplatin responders. We assessed quantitative measures of structural chromosomal instability (CIN) to identify a wider patient subgroup within TNT with preferential benefit from … WebbTNT A randomised phase III trial of carboplatin compared to docetaxel for patients with metastatic or recurrent locally advanced ER–, PR– and HER2– breast cancer. Disease site: Breast cancer Treatment modality: Systemic therapy … how to train older cats to use a litter box
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WebbWe assessed the efficacy of carboplatin and another mechanistically distinct therapy, docetaxel, in a phase 3 trial in subjects with unselected advanced TNBC. A prespecified … WebbしかしHER2陽性乳癌に対する分子標的治療の追加効果でpCRの改善が著明であるため期待さ れてきた。たとえばNOAH 試験(Giannni 2010 Lancet)は術前治療でTrastuzumab … http://web.tccf.org.tw/lib/addon.php?act=post&id=4216 how to train oily hair