Terpendole
WebAbstract. To reveal the mechanism of mitosis, the development of M phase-specific inhibitors is an important strategy. We have been screening microbial products to find specific M phase inhibitors that do not directly target tubulins, and rediscovered terpendole E (TerE) as a novel Eg5 inhibitor. TerE did not affect microtubule integrity in ... WebTerpendole M (1), a novel indole-diterpenoid, was isolated from perennial ryegrass (Lolium perenne) infected with the endophytic fungus Neotyphodium lolii. It was identified as 14alpha-hydroxyterpendole C by NMR and mass spectral techniques. The known indole-diterpenoids paspaline (3) and 13-desoxypaxilline (4) were also isolated from perennial ...
Terpendole
Did you know?
WebMay 5, 2014 · Terpendole E (TerE) is the first natural product that inhibits mitotic kinesin Eg5 (kinesin spindle protein). Recently, TerE is suggested to have a different binding site and/or inhibitory ... WebFeb 19, 2014 · In conclusion, the preparation of the DEF ring moiety (2) of terpendole E as its racemate was accomplished from the known keto ester 4 in 10 steps (36% overall yield) [or in 12 steps (56% overall yield) via 8].In this synthetic study, we found that the reduction of the ketone intermediate 8 with LiAlH 4 proceeded in an exclusively stereoselective …
http://www.fluoroprobe.com/archives/tag/ccd WebTerpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC50=145 µM). - Mechanism of Action & Protocol. From 11:00 pm to 12:00 pm …
WebTerpendole C is an acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor. Also acts as a tremorgen and cholesteryl ester (CE) synthesis inhibitor. We collect cookies for vital website function and to better serve our customers. WebTerpendole C ≥95% (by HPLC) Supplier: Adipogen. Description: Acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor. Tremorgenic. Cholesteryl ester (CE) synthesis inhibitor. Inquire for Price. Stock for this item is limited, but may be available in a warehouse close to you. ...
WebJan 21, 2015 · The challenging molecular architecture of 1 as well as its attractive pharmacological profiles prompted synthetic efforts toward 1, which led to the synthesis of 16-epi-terpendole E by Giannis and co-workers and a tricyclic right-hand moiety of 1 by the Oikawa group. 5,6) We have also addressed the total synthesis of terpendole E, and …
WebTerpenes are organic chemicals found in cannabis that give your flower her unique aroma and subtle taste. If you look closely at a bud, you’ll see tiny stalks with large bulbous … costco near red rock casinoWebThe first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence … macaroni grill italian nachosWebTerpendole C. Cat. No.: HY-N10224. Data Sheet Handling Instructions. Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase ( ACAT ). For research use only. costco near roswell nmmacaroni grill lasagnaTerpendole E is the first natural product inhibitor of kinesin Eg5. Because terpendole E production is unstable, we isolated and analyzed the terpendole E biosynthetic gene cluster, which consists of seven genes encoding three P450 monooxygenases (TerP, TerQ, and TerK), an FAD-dependent monooxygenase (TerM), a terpene cyclase (TerB), and two prenyltransferases (TerC and TerF). costco near pikesville mdWebTipindole definition: A serotonin antagonist . macaroni grill locations mnWebTerpendole M (1), a novel indole-diterpenoid, was isolated from perennial ryegrass (Lolium perenne) infected with the endophytic fungus Neotyphodium lolii. It was identified as 14alpha-hydroxyterpendole C by NMR and mass spectral techniques. The known indole-diterpenoids paspaline (3) and 13-desoxypaxilline (4) were also isolated from perennial ... costco near raleigh nc